Acknowledgements: authors thank Department of Restorative Dentistry of the Samara State Medical University for assistance in preparation of the materials and design of the manuscript.

Author contribution: Aptekar IA — study design and planning, literature analysis, data interpretation, manuscript authoring; Abramova EV — literature analysis, osteopathic data collection, data analysis and interpretation, manuscript authoring; Postnikov MA — editing; Kopetskiy IS, Postnikova EM, Poluianova EB — manuscript authoring; Eremin DA — analysis of the results; Aptekar VI, Muravyov IO — clinical trials, literature analysis, data interpretation, manuscript authoring.

Compliance with ethical standards: the study was approved by the Ethics Committee of the Research Centre for Medical Genetics (protocol № 4/2 dated 19 April 2021). The patients submitted the informed consent to participation in scientific research.